gene 1,505 words KG: ATG13 2026-03-27
kind:genesection:genestopic:parkinsonstopic:alzheimerstopic:alstopic:huntingtons
Contents

ATG13 — Autophagy Related 13

🧬 Gene Info
Gene SymbolATG13
Full NameAutophagy Related 13
Chromosome11p11.2
Functionis a critical gene encoding a key regulator of the autophagy initiation machinery in eukaryotic cells.
Molecular Weight60 kDa
Amino Acids559 aa
PathwaysApoptosis, Autophagy, Complement, Ferroptosis, Glycolysis
UniProt ID[Q9UQL6](https://www.uniprot.org/uniprot/Q9UQL6)
Ensembl IDENSG00000152256
OMIM614608
GeneCardsATG13
Human Protein AtlasATG13
Hor domain (HR)Located at the N-terminus, mediates protein-protein interactions
LIR (LC3-interacting region)At the C-terminus, enables binding to LC3/GABARAP family proteins
UBAN-like motifFacilitates interaction with specific autophagy receptors
Associated Diseasesneurodegeneration
InteractionsNCOA4, RAB7A, FUNDC1, ATG14, BECN1, BCL2L13
KG Connections196 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Circadian Clock-Autophagy Synchronization
Score: 0.55
Autophagosome Maturation Checkpoint Control
Score: 0.49
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits

Knowledge Graph (12 edges)

ATG13 contributes_to ATG5
ATG13 contributes_to BECN1
ATG13 activates NCOA4
ATG13 contributes_to ATG7
ATG13 activates RAB7A
ATG13 contributes_to ATG4B
ATG13 contributes_to ATG3
ATG13 interacts_with FUNDC1
ATG13 associated_with TAX1BP1
ATG13 associated_with NBR1