gene 874 words KG: ATG16L1 2026-03-24
kind:genesection:genesstate:published
Contents

ATG16L1 - Autophagy Related 16 Like 1

🧬 Gene Info
Gene SymbolATG16L1
Full NameAutophagy Related 16 Like 1
Chromosome2q37.1
Functionis a core autophagy protein essential for autophagosome formation and cellular protein quality control.
Primary Expressionneurons and glial cells throughout the brain, including the cortex, [hippocam
Amino Acids607 aa
PathwaysAkt, Autophagy, Epigenetic, Mapk, Mtor
Ensembl IDENSG00000085978
GeneCardsATG16L1
Human Protein AtlasATG16L1
Associated DiseasesInflammation, Intestinal Disease, Osteoarthritis, Parkinson, Rheumatoid Arthritis, Tumor
Known Drugs/Compoundsrapamycin
InteractionsRB1CC1, GABARAP, ERN1, STAT3, IFNG, LC3
KG Connections568 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (8)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (12)

Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: activates
ATG12 — Autophagy Related 12
gene · KG edge: activates
ATF6 - Activating Transcription Factor 6
gene · KG edge: regulates

Knowledge Graph (12 edges)

ATG16L1 interacts_with RB1CC1
ATG16L1 interacts_with GABARAP
ATG16L1 interacts_with ERN1
ATG16L1 interacts_with STAT3
ATG16L1 interacts_with IFNG
ATG16L1 interacts_with LC3
ATG16L1 interacts_with RPTOR
ATG16L1 interacts_with RB1
ATG16L1 interacts_with EIF2AK3
ATG16L1 interacts_with RIPK1