gene 828 words KG: ATG14 2026-03-22
kind:genesection:genesstate:published
Contents

ATG14 Gene

🧬 Gene Info
Gene SymbolATG14
Full NameAutophagy Related 14
Chromosome10q26.3
Functionis a crucial autophagy protein that plays a central role in the initiation of autophagosome formation.
Amino Acids492 aa
Exons12
PathwaysApoptosis, Autophagy, Cell Cycle, Epithelial-Mesenchymal Transition, Inflammasome
UniProt IDQ9Y5P8
NCBI Gene ID22889
Ensembl IDENSG00000131725
OMIM614113
GeneCardsATG14
Human Protein AtlasATG14
Associated DiseasesALS, Cancer, Infection, Lung Cancer, Tumor, dementia
InteractionsSTX17, BECN1, UVRAG, PIK3C3, TP53, LC3
KG Connections330 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50

Related Analyses (7)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: biomarker_for
Alzheimer Indonesia
institution · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: activates

Knowledge Graph (12 edges)

ATG14 associated_with GJA1
ATG14 regulates LAMP1
ATG14 interacts_with STX17
ATG14 biomarker_for ATG5
ATG14 associated_with GAPDH
ATG14 regulates TUBB3
ATG14 associated_with H2AX
ATG14 regulates RAB7
ATG14 regulates APP
ATG14 interacts_with BECN1