gene 1,666 words KG: ATG3 2026-04-01
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:als
Contents

ATG3 Gene

🧬 Gene Info
Gene SymbolATG3
Full NameAutophagy Related 3
Chromosome3q13.11
Functionis an essential autophagy gene encoding a ubiquitin-like conjugating enzyme that plays a critical role in autophagosome formation[@mizushima2011].
Molecular Weight~35 kDa
Amino Acids314 amino acids
Exons12
PathwaysApoptosis, Autophagy, Car-T, Immunotherapy, Tdp-43
GeneCardsATG3
Human Protein AtlasATG3
FeatureDetails
Genomic CoordinatesGRCh38: Chr3:112,456,789-112,501,234
Gene Length~45 kb
mRNA Variants4 major isoforms
Protein Length314 amino acids
Associated DiseasesALS, Inflammation, Ms, Osteoarthritis, Rheumatoid Arthritis
InteractionsNCOA4, RAB7A, ATG4B, CAT, TARDBP, ATG7
KG Connections252 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Cryptic Exon Silencing Restoration
Score: 0.46
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Cross-Seeding Prevention Strategy
Score: 0.45

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: regulates
ATG5 — Autophagy Related 5
gene · KG edge: activates
ATG4B — Autophagy Related 4B Cysteine Peptidase
gene · KG edge: activates

Knowledge Graph (12 edges)

ATG3 protects_against CD19 CAR-T cell cytotoxicity
ATG3 therapeutic_target ATG4B
ATG3 therapeutic_target TARDBP
ATG3 therapeutic_target CAT
ATG3 contributes_to ATG7
ATG3 contributes_to ATG13
ATG3 contributes_to ATG4B
ATG3 activates NCOA4
ATG3 activates RAB7A
ATG3 contributes_to BECN1