gene 769 words KG: ATG1 2026-03-24
kind:genesection:genesstate:published
Contents

ATG1

🧬 Gene Info
Gene SymbolATG1 (ULK1 in mammals)
Full NameUnc-51 Like Autophagy Activating Kinase 1
AliasesATG1, atg1
Chromosome12q13.12
Protein TypeSerine/Threonine Kinase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~105 kDa
PathwaysExocytosis
UniProt ID[Q9Y4P5](https://www.uniprot.org/uniprot/Q9Y4P5)
ULK1Catalytic serine/threonine kinase that initiates autophagy signaling
ATG13Regulatory subunit that enhances ULK1 activity and serves as a scaffold
FIP200Scaffold protein that recruits downstream effectors
ATG101Stabilizing subunit that protects ATG13 from degradation
Associated DiseasesAtaxia, Neurodegeneration
InteractionsULK1, P62, PI3K, ATG13, ATG5, MTOR
KG Connections60 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (8)

Packard Center for ALS Research
institution · KG edge: activates
CTSD — Cathepsin D
gene · KG edge: associated_with
CLN5 Gene - Ceroid Lipofuscinosis, Neuronal 5
gene · KG edge: associated_with
ATG5 — Autophagy Related 5
gene · KG edge: associated_with
ATG13 — Autophagy Related 13
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ATG1 associated_with ULK1
ATG1 associated_with ULK2
ATG1 activates ULK1
ATG1 activates P62
ATG1 interacts_with PI3K
ATG1 interacts_with ATG13
ATG1 interacts_with ATG5
ATG1 implicated_in SCA3
ATG1 implicated_in RAB7
ATG1 regulates ATG12