gene 769 words KG: ent-gene-a59a9e27
Contents

ATG1

🧬 Gene Info
Gene SymbolATG1 (ULK1 in mammals)
Full NameUnc-51 Like Autophagy Activating Kinase 1
AliasesATG1, atg1
Chromosome12q13.12
Protein TypeSerine/Threonine Kinase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~105 kDa
PathwaysExocytosis
UniProt ID[Q9Y4P5](https://www.uniprot.org/uniprot/Q9Y4P5)
ULK1Catalytic serine/threonine kinase that initiates autophagy signaling
ATG13Regulatory subunit that enhances ULK1 activity and serves as a scaffold
FIP200Scaffold protein that recruits downstream effectors
ATG101Stabilizing subunit that protects ATG13 from degradation
Associated DiseasesAtaxia, Neurodegeneration
InteractionsAMPK, AND, ATG, ATG13, ATG5, AUTOPHAGY
KG Connections58 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

APOE-Dependent Autophagy Restoration
Score: 0.89
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
VCP-Mediated Autophagy Enhancement
Score: 0.59

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATG12 — Autophagy Related 12
gene · KG edge: regulates
ATG13 — Autophagy Related 13
gene · KG edge: interacts_with
ATG5 — Autophagy Related 5
gene · KG edge: associated_with

Knowledge Graph (2 edges)

ent-gene-a59a9e27 data_in benchmark_ot_ad_answer_key:ATG1
benchmark_ot_ad_answer_key:ATG1 data_in ent-gene-a59a9e27

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