| Gene Symbol | ATL1 |
| Function | Atlastin-1 is a membrane-bound GTPase with essential functions in |
| GeneCards | ATL1 |
| Human Protein Atlas | ATL1 |
| Aspect | Details |
| Inheritance | Autosomal dominant |
| Prevalence | ~10% of autosomal dominant HSP |
| Mutations | Over 50 pathogenic variants identified |
| Age of Onset | Often childhood onset (youngest among HSPs) |
| Disease | Relationship |
| [Parkinson's Disease](/diseases/parkinsons-disease) | ATL1 expression altered in some PD models |
| Neurodevelopmental disorders | Rare reports of ATL1 involvement |
| Charcot-Marie-Tooth disease | Some phenotypic overlap |
| Strategy | Status |
| Gene therapy | Preclinical |
| Associated Diseases | ALS |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |