gene 3,019 words KG: PDHX 2026-03-27
kind:genesection:genesstate:published
Contents

PDHX Gene

🧬 Gene Info
Gene SymbolPDHX
Full NamePyruvate Dehydrogenase Complex Component X
Chromosome11p13
Protein TypeDehydrogenase
FunctionE1 (Pyruvate Dehydrogenase): Heterotetramer of PDHA1 (α2β2) that decarboxylates pyruvate
Primary ExpressionUbiquitous; highest in heart, brain, liver, and skeletal muscle
Molecular Weight54 kDa
Amino Acids501 aa
UniProt IDQ9BRU2
NCBI Gene ID5165
Ensembl IDENSG00000165478
OMIM608771
GeneCardsPDHX
Human Protein AtlasPDHX
Official SymbolPDHX
Associated DiseasesALS
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Packard Center for ALS Research
institution · KG edge: associated_with
SPAST
gene · KG edge: associated_with
SLC16A2 Gene (MCT8)
gene · KG edge: associated_with
SATB2 - Special AT-Rich Sequence Binding Protein 2
gene · KG edge: associated_with
GNAO1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PDHX associated_with SLC16A2
PDHX associated_with GNAO1
PDHX associated_with SATB2
PDHX associated_with SPAST
PDHX associated_with ATL1
PDHX associated_with Rb
PDHX associated_with POLR2A
PDHX associated_with Als
PDHX associated_with AND
PDHX associated_with ALS