| Gene Symbol | GNAO1 |
| Full Name | Guanine Nucleotide-Binding Protein Alpha O Subunit |
| Chromosome | 16q13 |
| Function | is a member of the Gi/o family of G proteins and regulates multiple downstream effectors including adenylyl cyclase, phospholipase C, and ion channels. |
| Molecular Weight | 40 kDa |
| Pathways | MAPK, PI3K pathway, MAPK Pathway |
| UniProt ID | P71275 |
| NCBI Gene ID | 2770 |
| Ensembl ID | ENSG00000187258 |
| OMIM | 139311 |
| GeneCards | GNAO1 |
| Human Protein Atlas | GNAO1 |
| GTPase domain | Binds and hydrolyzes GTP to regulate protein activity |
| Effector binding region | Interacts with downstream signaling molecules |
| N-terminal helix | Required for interaction with Gβγ subunits |
| Associated Diseases | ALS |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |