gene 2,721 words KG: SLC16A2 2026-03-28
kind:genesection:genesstate:published
Contents

SLC16A2 Gene (MCT8)

🧬 Gene Info
Gene SymbolSLC16A2 (MCT8)
Full NameSolute Carrier Family 16 Member 2 (Monocarboxylate Transporter 8)
AliasesSLC16A2
ChromosomeXq13.2
Protein Familytransporter
Target ClassTransporter
Mechanism of ActionSubstrate supplementation or transporter modulation
DruggabilityLow (0.39)
Clinical StagePhase I
PathwaysX chromosome, SLC16 family, thyroid function, Blood-Brain Barrier, Lactate/monocarboxylate transport
UniProt IDP36012
NCBI Gene ID6568
Ensembl IDENSG00000147100
R271HMissense
L471PMissense
Associated DiseasesALI, ALS, AMI, ARM, Aging, Allan-Herndon-Dudley syndrome
Known Drugs/CompoundsTriiodothyroacetic acid
InteractionsSLCO1C1, TH, CANCER, MICRORNAS, MIR-375, CYP2E1
SciDEX TargetView Target Profile (1 clinical trials)
SciDEX HypothesesAstrocytic Lactate Shuttle Enhancement for Grid Ce
KG Connections165 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (24)

Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (5)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · completed

Related Experiments (3)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
s:** - Test MCU overexpression specifically in layer II neur
falsification · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: associated_with
HCN1 Gene
gene · KG edge: co_discussed
GNAO1 Gene
gene · KG edge: associated_with
COL4A1 Gene
gene · KG edge: associated_with
C1QA Gene — Complement Component 1q A Chain
gene · KG edge: activates

Knowledge Graph (12 edges)

SLC16A2 associated_with neurodegeneration
SLC16A2 co_discussed RELN
SLC16A2 co_discussed MAP6
SLC16A2 co_discussed HCN1
SLC16A2 co_discussed MCU
SLC16A2 co_discussed IDH2
SLC16A2 regulates Astrocytic Lactate Shuttle Enhancement for Grid Ce
SLC16A2 regulates Tau Propagation
SLC16A2 associated_with SLC16A1
SLC16A2 therapeutic_target GSS