Contents

BSN Gene

🧬 Gene Info

Gene Symbol	BSN
Chromosome	3p21.31
Function	is a human gene that encodes one of the largest known synaptic proteins, with a molecular weight of approximately 420 kDa and about 3,948 amino acids[@gundelfinger2003].
Molecular Weight	420 kDa
Amino Acids	948 aa
Exons	63
Ensembl ID	ENSG00000184961
GeneCards	BSN
Human Protein Atlas	BSN
Hippocampus	Particularly high expression in CA3 pyramidal neurons and dentate gyrus granule cells, where Bassoon is enriched at mossy fiber synapses[@dieck1998]
Cerebral Cortex	Broad expression across all cortical layers, with particular enrichment in layer 2/3 pyramidal neurons
Cerebellum	Expression in Purkinje cells and granule cells
Retina	Very high expression in photoreceptor cells and bipolar cells, where Bassoon is a core component of synaptic ribbons
Substantia Nigra	Expression in dopaminergic neurons[@yoshida2012]
Associated Diseases	neurodegeneration
Interactions	CELF4, GBA, NRXN1
KG Connections	18 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph