gene

CELF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

3Outgoing

4Incoming

Summary

CELF4 is an RNA-binding protein critical for neuronal splicing regulation. Variants cause epilepsy, autism, and may contribute to Alzheimer's and Parkinson's disease through dysregulated RNA processing.

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🧬 Gene Info

Gene Symbol	CELF4
Full Name	CUGBP Elav-Like Family Member 4
Chromosome	18q12.2
Function	is a member of the CELF family of RNA-binding proteins that play critical roles in post-transcriptional gene regulation in neurons.
Subcellular Localization	[@baralle2018]
Amino Acids	90 aa
UniProt ID	Q9Y5J7
NCBI Gene ID	56853
Ensembl ID	ENSG00000149150
OMIM	607666
GeneCards	CELF4
Human Protein Atlas	CELF4
Previous Names	BRUNOL4
Interactor	Function
CELF1	Cooperative splicing regulation
Associated Diseases	Alzheimer's disease, Parkinson's disease, Epilepsy
Interactions	NRXN1, BSN, GBA
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CELF4 — AlphaFold Q9Y5J7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CELF4["<b>CELF4</b>"]
    Aging{"Aging"}
    CELF4 -->|"expressed in"| Aging
    Ms{"Ms"}
    CELF4 -->|"expressed in"| Ms
    Depression{"Depression"}
    CELF4 -->|"expressed in"| Depression
    neurodegeneration["neurodegeneration"]
    CELF4 -->|"implicated in"| neurodegeneration
    GUT_BRAIN_AXIS["GUT-BRAIN AXIS"]
    GUT_BRAIN_AXIS -->|"regulates"| CELF4
    NRXN1["NRXN1"]
    NRXN1 -->|"activates"| CELF4
    BSN["BSN"]
    BSN -->|"activates"| CELF4
    GBA["GBA"]
    GBA -->|"activates"| CELF4
    style CELF4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (3)

Target	Relation	Type	Str
Aging	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65

Incoming (4)

Source	Relation	Type	Str
NRXN1	activates	gene	0.60
BSN	activates	gene	0.60
GBA	activates	gene	0.60
GUT-BRAIN AXIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found