protein 1,622 words KG: ATP13A2 2026-03-24
kind:proteinsection:proteinsstate:published
Contents

ATP13A2 Protein (PARK9)

🔬 Protein Info
Gene SymbolATP13A2
Full NameATP13A2 (PARK9)
AliasesATPase Cation Transporting 13A2
Chromosome1p36.13
Protein TypeProtein
Functionis a member of the P-type ATPase family that functions as a lysosomal cation transporter, primarily pumping manganese and other cations across the lysosomal membrane[@ramirez2006].
Primary ExpressionSubstantia nigra, Basal ganglia, Cerebral cortex
Subcellular LocalizationLysosomes, Late endosomes
Molecular Weight446 kDa
Amino Acids978 aa
PathwaysAutophagy
UniProt IDQ9BYU8
Ensembl IDENSG00000159363
GeneCardsATP13A2
Human Protein AtlasATP13A2
Associated DiseasesALS, AMYOTROPHIC LATERAL SCLEROSIS, Aging, Alzheimer
InteractionsVPS35, EIF4G1, PARKIN, NLRP3, FA2H, DNAJC6
KG Connections381 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (10)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (2)

Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

ATP13A2 therapeutic_target GAIN
ATP13A2 therapeutic_target LRRK2
ATP13A2 therapeutic_target PRKN
ATP13A2 therapeutic_target PINK1
ATP13A2 associated_with LRRK2
ATP13A2 associated_with PINK1
ATP13A2 associated_with PRKN
ATP13A2 co_discussed LRRK2
ATP13A2 co_discussed PINK1
ATP13A2 co_discussed PRKN