gene 1,046 words KG: CFOS 2026-03-24
kind:genesection:genesstate:published
Contents

CFOS Gene

🧬 Gene Info
Gene SymbolCFOS
Full NameFBJ murine osteosarcoma viral oncogene homolog
Chromosome14q24.3
Protein FamilyFos transcription factor family (c-Fos, FosB, Fra-1, Fra-2)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight62 kDa
Amino Acids380 aa
Exons4
PathwaysAmyloid, Blood-Brain Barrier
GeneCardsCFOS
Human Protein AtlasCFOS
DNA-binding domainCentral (140-200 aa)
Leucine zipperC-terminal (200-280 aa)
Associated Diseasesneurodegeneration
InteractionsDLK, APP, RANK, APOE4, APOE, ERK1
KG Connections43 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1
gene · KG edge: activates

Knowledge Graph (12 edges)

CFOS activates DLK
CFOS activates APP
CFOS activates RANK
CFOS activates APOE4
CFOS activates APOE
CFOS activates ERK1
CFOS activates BDNF
CFOS expressed_in Rb
CFOS activates APOE3
CFOS activates ALZHEIMER