gene 625 words KG: DLK 2026-03-27
kind:genesection:genesstate:published
Contents

DLK — Dual Leucine Zipper Kinase

🧬 Gene Info
Gene SymbolDLK
Full NameDual Leucine Zipper Kinase
AliasesMAP3K12
Protein TypeKinase
FunctionDLK functions as a master regulator of the stress-activated protein kinase (SAPK) signaling cascade:
Molecular Weight105 kDa
Pathwayscascade: ### Axonal Injury Response
Ensembl IDENSG00000116809
GeneCardsDLK
Human Protein AtlasDLK
Associated DiseasesAging
InteractionsPUMA, APP, RANK, APOE4, APOE, CFOS
KG Connections108 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: causes
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

DLK activates PUMA
DLK activates APP
DLK activates RANK
DLK activates APOE4
DLK activates APOE
DLK activates CFOS
DLK activates ERK1
DLK causes DRP1
DLK activates Mitochondrial Fission
DLK phosphorylates DRP1