gene 723 words KG: RANK 2026-03-21
kind:genesection:genesstate:published
Contents

RANK (TNFRSF11A)

🧬 Gene Info
Gene SymbolRANK (TNFRSF11A)
Full NameTNF Receptor Superfamily Member 11A
AliasesTNFRSF11A
Chromosome18q21.33
Protein TypeReceptor
FunctionRANK is a type I transmembrane protein expressed primarily on osteoclast precursors, dendritic cells, and activated T cells[@anderson1997].
PathwaysNF-κB
UniProt IDQ9Y275
NCBI Gene ID26986
Ensembl IDENSG00000141655
OMIM603799
Associated DiseasesALS, Aging, Autoimmune, Cancer, Hypertension
InteractionsRANKL, TIA1, GAIN, HNRNPA2B1, HNRNPA1, TYROBP
KG Connections416 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (17)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (5)

Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
ALDH2 — Aldehyde Dehydrogenase 2
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

RANK regulates TYROBP
RANK interacts_with RANKL
RANK activates RANKL
RANK activates TIA1
RANK activates GAIN
RANK activates HNRNPA2B1
RANK activates HNRNPA1
RANK activates TYROBP
RANK regulates RANKL
RANK regulates ATF4