gene 724 words KG: CHL1
Contents

CHL1 Gene

🧬 Gene Info
Gene SymbolCHL1
Full NameCHL1 Neural Cell Adhesion Molecule
Chromosome3p26.3
Functionencodes a neural cell adhesion molecule belonging to the L1 family of immunoglobulin superfamily CAMs.
Primary Expressionthe nervous system:
Molecular Weight200 kDa
Amino Acids209 aa
UniProt IDP0CAT4
NCBI Gene ID10752
Ensembl IDENSG00000113838
OMIM300114
GeneCardsCHL1
Human Protein AtlasCHL1
Extracellular domainContains 6 Ig-like domains and 5 fibronectin type III repeats, mediating homophilic and heterophilic interactions
Transmembrane domainSingle pass transmembrane region
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Membrane Cholesterol Gradient Modulators
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
BACE1 (Redirect)
redirect · KG edge: associated_with
GATA2 - GATA Binding Protein 2
gene · KG edge: therapeutic_target
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
TIMP1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TIMP1 associated_with CHL1
GATA2 therapeutic_target CHL1
PDGFRB associated_with CHL1
APP mediates CHL1
BACE1 co_mentioned CHL1
VPS35 regulates CHL1
BACE1 targets CHL1
CHL1 targets epilepsy
ALZHEIMER'S DISEASE therapeutic_target CHL1
IMMUNE INFILTRATION therapeutic_target CHL1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.