gene 724 words KG: CHL1 2026-03-22
kind:genesection:genesstate:published
Contents

CHL1 Gene

🧬 Gene Info
Gene SymbolCHL1
Full NameCHL1 Neural Cell Adhesion Molecule
Chromosome3p26.3
Functionencodes a neural cell adhesion molecule belonging to the L1 family of immunoglobulin superfamily CAMs.
Primary Expressionthe nervous system:
Molecular Weight200 kDa
Amino Acids209 aa
UniProt IDP0CAT4
NCBI Gene ID10752
Ensembl IDENSG00000113838
OMIM300114
GeneCardsCHL1
Human Protein AtlasCHL1
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Membrane Cholesterol Gradient Modulators
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: therapeutic_target
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: mediates
TIMP1 Gene
gene · KG edge: associated_with
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CHL1 targets epilepsy
CHL1 therapeutic_target Alzheimer
CHL1 therapeutic_target Als
CHL1 therapeutic_target Ms
CHL1 correlates_with Alzheimer's Disease
TIMP1 associated_with CHL1
GATA2 therapeutic_target CHL1
PDGFRB associated_with CHL1
APP mediates CHL1
BACE1 co_mentioned CHL1