gene 1,090 words KG: GATA2 2026-03-22
kind:genesection:genesstate:published
Contents

GATA2 - GATA Binding Protein 2

🧬 Gene Info
Gene SymbolGATA2
Full NameGATA Binding Protein 2
AliasesPage for GATA2
Protein TypeTranscription Factor
FunctionGATA2 functions as a dual-function transcription factor with roles in development and adult tissue homeostasis:
Primary Expressionpremigratory and migrating neural crest cells, where it regulates genes involved in melanocyte, Schwann cell, and peripheral neuron development
PathwaysApoptosis, Cholesterol
Ensembl IDENSG00000179348
GeneCardsGATA2
Human Protein AtlasGATA2
Associated DiseasesALS, Alzheimer, Infection, Inflammation, Lymphoma
InteractionsMST1, IL6, ANG, CXCL8, CXCL1, TNF
KG Connections162 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Aquaporin-4 Polarization Rescue
Score: 0.51

Related Analyses (6)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
ESR1 — Estrogen Receptor Alpha
gene · KG edge: regulates
EGR1 Gene
gene · KG edge: protects_against

Knowledge Graph (12 edges)

GATA2 regulates NFATC1
GATA2 activates MST1
GATA2 therapeutic_target PDGFRB
GATA2 therapeutic_target CHL1
GATA2 therapeutic_target EGF
GATA2 therapeutic_target CDC42
GATA2 therapeutic_target EP300
GATA2 therapeutic_target ESR1
GATA2 therapeutic_target ATM
GATA2 regulates JUN