gene 610 words KG: TIMP1 2026-03-24
kind:genesection:genesstate:published
Contents

TIMP1 Gene

🧬 Gene Info
Gene SymbolTIMP1
FunctionTIMP1 encodes tissue inhibitor of metalloproteinases 1, a member of the TIMP family that regulates matrix metalloproteinases (MMPs).
Primary Expressionastrocytes and can be induced by injury and inflammation
PathwaysAutophagy, Angiogenesis, senescence, oxidative stress response, circadian regulation
Ensembl IDENSG00000102265
GeneCardsTIMP1
Human Protein AtlasTIMP1
Associated Diseasesneurodegeneration
InteractionsLGALS3, CD14, RGS1, ATF3, VIM, STAT4
KG Connections83 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (20)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (8)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: therapeutic_target
LRP1-Enhanced Perivascular Drainage Therapy
idea · KG edge: associated_with
CX3CR1 Modulation Therapy for Neurodegeneration
idea · KG edge: co_discussed
SPP1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TIMP1 inhibits MMP9
TIMP1 protects_against neuropathic pain
TIMP1 activates LGALS3
TIMP1 activates CD14
TIMP1 activates RGS1
TIMP1 activates ATF3
TIMP1 activates VIM
TIMP1 therapeutic_target GATA2
TIMP1 associated_with PDGFRB
TIMP1 associated_with CHL1