gene 610 words KG: TIMP1
Contents

TIMP1 Gene

🧬 Gene Info
Gene SymbolTIMP1
FunctionTIMP1 encodes tissue inhibitor of metalloproteinases 1, a member of the TIMP family that regulates matrix metalloproteinases (MMPs).
Primary Expressionastrocytes and can be induced by injury and inflammation
PathwaysAutophagy, Angiogenesis, senescence, oxidative stress response, circadian regulation
Ensembl IDENSG00000102265
GeneCardsTIMP1
Human Protein AtlasTIMP1
Associated Diseasesneurodegeneration
InteractionsANXA2, ASTROCYTES, ATF3, BMAL1, C3, CD14
KG Connections85 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
SASP-Mediated Complement Cascade Amplification
Score: 0.82
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67

Related Analyses (8)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed

See Also (15)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: activates
IL6 (Redirect)
redirect · KG edge: regulates
Microglia in Neurodegeneration
entity · KG edge: activates
Genes
index · KG edge: expressed_in

Knowledge Graph (12 edges)

EZH2 regulates TIMP1
TIMP1 inhibits MMP9
substance P inhibits TIMP1
TIMP1 protects_against neuropathic pain
IL12B expressed_in TIMP1
ITPR1 expressed_in TIMP1
MAP1LC3B expressed_in TIMP1
ANXA2 activates TIMP1
ICAM1 activates TIMP1
CD44 activates TIMP1

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