gene 1,841 words KG: CLCN1 2026-03-14
kind:genesection:genesstate:published
Contents

CLCN1 (Chloride Voltage-Gated Channel 1)

🧬 Gene Info
Gene SymbolCLCN1
AliasesChloride Voltage-Gated Channel 1
Chromosome7q34
Protein TypeChannel
FunctionCLC-1 is a homodimeric voltage-gated chloride channel belonging to the CLC chloride channel family.
Primary ExpressionSkeletal muscle (type I and type II fibers)
Amino Acids994 aa
Pathwaysinsulin signaling
UniProt IDP35523
NCBI Gene ID1187
Ensembl IDENSG00000100137
OMIM118425
GeneCardsCLCN1
Human Protein AtlasCLCN1
Gene NameChloride Voltage-Gated Channel 1
Associated DiseasesMuscle weakness, Myotonia, neurodegeneration
Known Drugs/CompoundsNMD670
InteractionsHsp90β, FKBP8, GSK3β
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (4)

SP1 (Specificity Protein 1)
gene · KG edge: regulates
mbnl1
gene · KG edge: associated_with
CRYAB Gene
gene · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

CLCN1 associated_with CryAB
CLCN1 regulates CUGBP1
CLCN1 regulates Sp1
CLCN1 associated_with IR
CLCN1 associated_with MBNL1
CLCN1 associated_with MTMR1
CLCN1 upregulates Manumycin A
CLCN1 inhibits NMD670
CLCN1 interacts_with Hsp90β
CLCN1 interacts_with FKBP8