Contents

SP1 (Specificity Protein 1)

🧬 Gene Info

Gene Symbol	SP1
Full Name	SP1 (Specificity Protein 1)
Aliases	Specificity Protein 1
Protein Type	Gene
Function	The SP1 gene encodes Specificity Protein 1 (Sp1), a zinc finger transcription factor that binds to GC-rich promoter elements and regulates the expression of numerous genes including housekeeping genes
Pathways	Akt, Epigenetic, Pi3K
GeneCards	SP1
Human Protein Atlas	SP1
GC-box	5'-GGGGCGG-3' sequences in gene promoters
GT-box	Similar regulatory elements
Gene Expression Regulation	Controls numerous neuronal genes including those involved in synaptic function
Cell Survival	Exhibits anti-apoptotic functions through regulation of Bcl-2 family genes
Amyloid Processing	Directly regulates APP and BACE1 expression
[Tau](/proteins/tau) Phosphorylation	Influences tau metabolism through transcriptional regulation
Associated Diseases	Als, Alzheimer, Ms
Known Drugs/Compounds	Glucosamine
Interactions	AND, APP, ATP2A3, CANCER, CHOP, DKK1
KG Connections	159 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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