gene 2,787 words KG: MBNL1
Contents

MBNL1 Gene

🧬 Gene Info
Gene SymbolMBNL1
FunctionMBNL1 is a zinc finger RNA-binding protein that regulates alternative splicing, RNA localization, and RNA stability through binding to specific sequence motifs[@charizanis2012]:
Primary ExpressionWhite Matter
Pathwaysinsulin signaling
Ensembl IDENSG00000138700
GeneCardsMBNL1
Human Protein AtlasMBNL1
Associated DiseasesHuntington's disease
InteractionsMBNL2, DMPK, RNA, AND, Proteins
KG Connections30 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47

Related Analyses (8)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (6)

Proteins
index · KG edge: interacts_with
MBNL2 Gene
gene · KG edge: expressed_in
DMPK Gene (Dystrophia Myotonica Protein Kinase)
gene · KG edge: inhibits
CLCN1 (Chloride Voltage-Gated Channel 1)
gene · KG edge: associated_with
BDNF Gene
gene · KG edge: regulates_retrograde_signaling_

Knowledge Graph (12 edges)

MBNL1 interacts_with MBNL2
MBNL1 interacts_with DMPK
MBNL1 inhibits DMPK
MBNL1 expressed_in MBNL2
MBNL1 regulates_retrograde_signaling_of BDNF
MBNL1 participates_in insulin signaling
MBNL1 interacts_with RNA
MBNL1 inhibits RNA
MBNL1 inhibits AND
MBNL1 expressed_in White Matter