gene

CRYAB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRYAB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Crystallin Alpha B - small heat shock protein with chaperone activity in neurodegeneration

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🧬 Gene Info

Gene Symbol	CRYAB
Full Name	Crystallin Alpha B
Chromosome	11q23.1
Function	The CRYAB gene encodes αB-crystallin (also known as CRYAB or HspB5), a small heat shock protein (sHsp) that functions as a molecular chaperone
Primary Expression	many tissues including the brain, heart, and skeletal muscle, where it plays critical roles in protein quality control and cellular protection[@jin202
Subcellular Localization	Oxidation: Oxidative stress can modify cysteine residues, altering function
Pathways	MAPK signaling, Mapk, P38 Mapk, Proteostasis, lipid metabolism
UniProt ID	P02511
NCBI Gene ID	1410
Ensembl ID	ENSG00000109846
OMIM	123590
GeneCards	CRYAB
Human Protein Atlas	CRYAB
N-terminal domain	Contains the WDPF motif and hydrophobic regions for client binding
C-terminal domain	Contains the α-crystallin domain characteristic of sHsp family
Associated Diseases	Als, Alzheimer, Cancer, Diabetes, Ms, Tumor
Interactions	HSPA8, SYNGR3, P38, PRDX6, CLU, TNF
KG Connections	148 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CRYAB — AlphaFold P02511 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CRYAB["<b>CRYAB</b>"]
    Als{"Als"}
    CRYAB -->|"therapeutic target"| Als
    Parkinson{"Parkinson"}
    CRYAB -->|"interacts with"| Parkinson
    CRYAB -->|"interacts with"| Als
    Dementia{"Dementia"}
    CRYAB -->|"interacts with"| Dementia
    Ms{"Ms"}
    CRYAB -->|"associated with"| Ms
    CASP3["CASP3"]
    CRYAB -->|"therapeutic target"| CASP3
    Mapk(["Mapk"])
    CRYAB -->|"therapeutic target"| Mapk
    HSPA8["HSPA8"]
    CRYAB -->|"interacts with"| HSPA8
    SYNGR3["SYNGR3"]
    CRYAB -->|"interacts with"| SYNGR3
    neurodegeneration["neurodegeneration"]
    CRYAB -->|"implicated in"| neurodegeneration
    GFAP["GFAP"]
    GFAP -->|"therapeutic target"| CRYAB
    NDUFV1["NDUFV1"]
    NDUFV1 -->|"therapeutic target"| CRYAB
    MAPK14["MAPK14"]
    MAPK14 -->|"therapeutic target"| CRYAB
    PLEC["PLEC"]
    PLEC -->|"therapeutic target"| CRYAB
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| CRYAB
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"interacts with"| CRYAB
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| CRYAB
    GFAP -->|"associated with"| CRYAB
    style CRYAB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (91)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Senescence	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	causes	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
CASP3	therapeutic_target	gene	0.60
HSPA8	interacts_with	gene	0.60
SYNGR3	interacts_with	gene	0.60
P38	activates	gene	0.60
CPT2	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
TP53	biomarker_for	gene	0.60
PI3K	associated_with	gene	0.60
IL1B	biomarker_for	gene	0.60
PRDX6	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
SERPINA3	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
CD44	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
CATHEPSINS	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
IL6	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
MMP1	associated_with	gene	0.60
MT1A	associated_with	gene	0.60
NOS1	associated_with	gene	0.60
PRDX6	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
neuroinflammation	associated_with	disease	0.60
Mapk	therapeutic_target	pathway	0.60

Incoming (60)

Source	Relation	Type	Str
GFAP	therapeutic_target	gene	0.60
NDUFV1	therapeutic_target	gene	0.60
MAPK14	therapeutic_target	gene	0.60
PLEC	therapeutic_target	gene	0.60
GFAP	associated_with	gene	0.60
TAU	activates	gene	0.60
P38	activates	gene	0.60
MAPK1	associated_with	gene	0.60
HDAC3	associated_with	gene	0.60
DNAJB1	biomarker_for	gene	0.60
HSP90AA1	biomarker_for	gene	0.60
NOS1	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
SERPINA3	interacts_with	gene	0.60
PRDX6	interacts_with	gene	0.60
MT1A	interacts_with	gene	0.60
CD44	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
MMP1	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
CATHEPSINS	associated_with	gene	0.60
LRP1	interacts_with	gene	0.60
CLU	associated_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
MAPK	activates	gene	0.60
AND	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
AGING	biomarker_for	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	biomarker_for	gene	0.60
ASTROCYTE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NEUROINFLAMMATION	interacts_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
HSPB1	associated_with	gene	0.60
APOE	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CRYAB

Understanding Entity Pages

Summary

Wiki Pages (21)

CRYAB Gene

Striatal Medium Spiny Neurons in Neurodegenerative Disease

Protein Clearance Mechanisms

αB-Crystallin (CRYAB)

HSPB2 Gene (Heat Shock Protein Family B Member 2)

Heat Shock Proteins

GFAP Protein

Protein Folding in Neurodegeneration

HSPB5 Protein — Alpha B-Crystallin

Alexander Disease Genetic Variants

heat-shock-response-neurodegeneration

HSF2 — Heat Shock Transcription Factor 2

HSPB5 — Heat Shock Protein Beta 5

MT1A (Metallothionein-1A)

Müller Glial Cells

HSPB3 Gene

Cathepsin S Protein

SYNGR3 Gene

NDUFV1 Gene