entity

IR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

30Hypotheses

30Analyses

50Outgoing

27Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (50)

Target	Relation	Type	Str
neuroinflammation	activates	disease	0.70
macrophages	expressed_in	cell_type	0.70
PI3K	activates	gene	0.60
neurodegeneration	activates	disease	0.60
MAP2	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
TNF	activates	gene	0.60
stroke	activates	disease	0.60
MET	activates	gene	0.60
MET	biomarker_for	gene	0.60
PSEN1	regulates	gene	0.60
neurodegeneration	interacts_with	disease	0.60
neuroinflammation	interacts_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
neuroinflammation	associated_with	disease	0.60
ferroptosis	participates_in	pathway	0.60
TGM2	inhibits	gene	0.60
neurodegeneration	implicated_in	disease	0.60
neurodegeneration	inhibits	disease	0.60
LRP2	targets	gene	0.60
LRP2	regulates	gene	0.60
TH	expressed_in	gene	0.60
JNK	activates	gene	0.60
NBS1	inhibits	gene	0.60
PARP1	inhibits	gene	0.60
RAD51	inhibits	gene	0.60
diabetes	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
diabetes	activates	disease	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
Alzheimer's disease	associated_with	disease	0.60
LDL	associated_with	gene	0.60
synaptic plasticity	participates_in	pathway	0.60
diabetes	protects_against	disease	0.60
PINK	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
Alzheimer's disease	activates	disease	0.60
apoptosis pathway	participates_in	pathway	0.60
Alzheimer's disease	implicated_in	disease	0.60
senescence	participates_in	pathway	0.60
TGF	interacts_with	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
RNA	interacts_with	gene	0.60
neurons	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55
astrocytes	expressed_in	cell_type	0.55
benchmark_ot_ad_answer_key:IR	data_in	dataset_row	0.00

Incoming (27)

Source	Relation	Type	Str
CLCN1	associated_with	gene	0.70
DNA	inhibits	gene	0.70
AKT	activates	gene	0.60
GFAP	implicated_in	gene	0.60
GFAP	interacts_with	gene	0.60
BACE1	activates	gene	0.60
CERS2	activates	gene	0.60
ALOX12	associated_with	gene	0.60
ALOX12	implicated_in	gene	0.60
CP	associated_with	gene	0.60
ANGPT1	activates	gene	0.60
HDAC3	activates	gene	0.60
HDAC3	protects_against	gene	0.60
HDAC3	associated_with	gene	0.60
HDAC3	inhibits	gene	0.60
H2AX	activates	gene	0.60
H2AX	associated_with	gene	0.60
ATM	inhibits	gene	0.60
AMPK	activates	gene	0.60
HIF	activates	gene	0.60
metformin	targets	drug	0.60
INS	biomarker_for	gene	0.60
DNA	activates	gene	0.60
rapamycin	targets	drug	0.60
DNA	implicated_in	gene	0.60
DNA	interacts_with	gene	0.60
benchmark_ot_ad_answer_key:IR	data_in	dataset_row	0.00

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa	0.700	-	Do β-amyloid plaques and neurofibrillary
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.677	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Nutrient-Sensing Epigenetic Circuit Reactivation	0.670	neurodegeneration	Epigenetic reprogramming in aging neuron

Circadian Glymphatic Entrainment via Targeted Orexin Recepto	0.623	neurodegeneration	Perivascular spaces and glymphatic clear
Alpha-gamma cross-frequency coupling enhancement to restore	0.621	Alzheimer's disease	Circuit-level neural dynamics in neurode
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici	0.609	neurodegeneration	Should microtubule-stabilizing drugs be
Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Choli	0.600	-	Do β-amyloid plaques and neurofibrillary
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.600	neurodegeneration	Gene expression changes in aging mouse b
H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from	0.588	neurodegeneration	How does APOE4's beneficial immune funct
Prefrontal sensory gating circuit restoration via PV interne	0.587	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging	0.587	neurodegeneration	Gene expression changes in aging mouse b
Circadian-Synchronized Proteostasis Enhancement	0.584	neurodegeneration	Digital biomarkers and AI-driven early d
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.576	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Circadian Clock-Autophagy Synchronization	0.547	neurodegeneration	Sleep disruption as cause and consequenc
Circadian Glymphatic Rescue Therapy (Melatonin-focused)	0.546	neurodegeneration	Sleep disruption as cause and consequenc
Retinal Vascular Microcirculation Rescue	0.542	neurodegeneration	Digital biomarkers and AI-driven early d
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
Circadian-Synchronized LRP1 Pathway Activation	0.526	neurodegeneration	Blood-brain barrier transport mechanisms
TREM2 Agonism to Redirect Microglia from Synaptic Pruning to	0.521	neurodegeneration	How do ALS-associated OPTN mutations mec
Temporal Decoupling via Circadian Clock Reset	0.516	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi	0.511	neurodegeneration	CRISPR-based therapeutic approaches for
Hepcidin-Iron Set Point Hypothesis	0.511	endocrinology	Does TRT-induced erythrocytosis actually
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.509	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Dual-Circuit Tau Vulnerability Cascade	0.499	neuroscience	Circuit-level neural dynamics in neurode
SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R	0.498	neuropharmacology	What determines blood-brain barrier pene
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.494	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (30)

Scientific analyses that reference this entity

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.609

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.544

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868]	Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X	Pharmacol Rep	2025	1
Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662]	Dashti HS, Daghlas I, Lane JM, Huang Y,	Nat Commun	2021	1
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813]	Sun Y, Tisdale RK, Kilduff TS	Front Neurol Neurosci	2021	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle st [PMID:41915008]	Ma M, Ma R, Li Z, Shen S, Kong W, Qiu T,	Journal of molecular cell biol	2026	0
Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in Chronic Cerebr [PMID:41879438]	Zhou L, Jia J, Li J, Yao Z, Fu Z, Wang S	Current neuropharmacology	2026	0
Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications [PMID:41830033]	Jalouli M, Harrath AH, Al-Zharani M, Rah	Nutrients	2026	0
Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in [PMID:41645754]	Li W, Wang WH, Song Y, Li XJ, Li Y et al	Int J Mol Med	2026	0
Unravelling the therapeutic potential of chrysin against ischemic stroke and pos [PMID:41687709]	Achar PG, Krishna KL, C P K, Patil M, Pr	Neuroscience	2026	0
Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD [PMID:41709697]	Lagartos-Donate MJ, Escobar-Doncel B, Zh	Brain	2026	0
SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therape [PMID:41934491]	Alameen AAM, Al-Kuraishy HM, Al-Gareeb A	Neuromolecular Med	2026	0
Valsartan promotes neuroprotection in Parkinson's disease via epigenetic modulat [PMID:41936814]	Gowied HG, El-Mezayen NS, Afify EA	Life Sci	2026	0
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579]	Wu K, Wang N, Zhao D, Wei W, Zhang W et	Zhejiang Da Xue Xue Bao Yi Xue	2026	0
Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases. [PMID:41759326]	Shah A, Doshi G	Ageing research reviews	2026	0
Urolithin A Reverses Intranigral Rotenone-Generated Parkinsonism by Modulating D [PMID:41880654]	Devi A, Singh SB, Srivastava S, Dandekar	ACS chemical neuroscience	2026	0
Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can [PMID:41902653]	Merlo S, Lipari CLR, Patti A, Sortino MA	Phytotherapy research : PTR	2026	0
Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic net [PMID:41692938]	Ungvari Z, Menyhárt O, Ocana A, Lehoczki	GeroScience	2026	0
All the Way: A Decade of SIRT1 in Breast Cancer. [PMID:41898317]	Pratelli G, Montalbano M, Affranchi F, O	Biomedicines	2026	0
Therapeutic potential of sulforaphane in neurodegenerative diseases: mechanistic [PMID:41894075]	Kuwar OK, Tejpal S, Sharma V, Sharma A,	Molecular biology reports	2026	0
Uncovering the metabolic-epigenetic links between gene expression and stroke: in [PMID:41877258]	Kan J, Hong Y, Min R, Zhang B, Wang H	Neurological research and prac	2026	0

IR

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

GSK-3β in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

ftd-tdp-pathology

dendritic-spines

Ferroptosis in Alzheimer's Disease

TDP-43 Proteinopathy

metal-ion-synuclein-mitochondria-axis-parkinsons

Insulin Signaling in Parkinson's Disease

ATP5F1 — ATP Synthase F1 Subunit Beta

IGF-1 Signaling Pathway in Neurodegeneration

proteasome-ubiquitin-system-dysfunction-parkinsons

TYNDASE — Tyndall

metabolic-dysfunction-neurodegeneration

Motor Neuron Disease (MND)

DDX3X Gene

Blarcamesine

Metal Homeostasis Dysfunction Comparison Across Neurodegenerative Diseases

Outgoing (50)

Incoming (27)

Targeting Hypotheses (30)

Mentioning Analyses (30)

Are interneuron oscillation deficits compensatory responses or primary pathologi

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What are the specific circulating factors in exercise-conditioned plasma that me

How does APOE4's beneficial immune function reconcile with its established role

How do P/Q channel deficits paradoxically increase thalamic excitability despite

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

What is the relative contribution of connexin-43 gap junctions vs tunneling nano

Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically re

Does human glymphatic function show clinically relevant circadian variation like

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

What is the temporal sequence of sleep disruption versus amyloid-beta accumulati

What are the optimal timing windows for TREM2 agonism vs antagonism across disea

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

Do circadian disruptions cause neurodegeneration or result from it?

What is the optimal BBB opening duration and spatial precision to maximize thera

Do migratory animals encode specific spatial locations epigenetically or rely on

Does tau aggregation specifically cause PS externalization in vesicles independe

Can circadian interventions selectively target microglia without affecting other

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Do tau strains or regional cellular environments primarily drive PSP vs CBD path

Related Papers (20)