gene 1,549 words KG: CLCN8 2026-03-25
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

CLCN8 — Chloride Voltage-Gated Channel 8

🧬 Gene Info
Gene SymbolCLCN8
Full NameCLCN8 — Chloride Voltage-Gated Channel 8
Chromosome8q24.22
Protein TypeGene
Functionis a human gene encoding a voltage-gated chloride channel protein belonging to the CLCN family of chloride channels and transporters[@jentsch2000].
Primary Expressionthe central nervous system where it plays critical roles in neuronal chloride homeostasis and synaptic inhibition[@staley2006]
Molecular Weight88 kDa
Amino Acids803 aa
Exons26
NCBI Gene IDSearch NCBI
GeneCardsCLCN8
Human Protein AtlasCLCN8
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (5)

Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (4)

Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: associated_with
PIK3CA Gene
gene · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Notch and Gamma-Secretase Modulators for Parkinson's Di
company · KG edge: associated_with

Knowledge Graph (10 edges)

CLCN8 associated_with Wnt/β-Catenin
CLCN8 associated_with Hippo
CLCN8 associated_with InsP3/Ca2+
CLCN8 associated_with antisense oligonucleotides
CLCN8 associated_with PIK3CA
CLCN8 associated_with CAPN6
CLCN8 associated_with transcription factors
CLCN8 associated_with PI3K/AKT
CLCN8 associated_with Notch
CLCN8 associated_with IL-1β