concept

PI3K/AKT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2006Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PI3K/AKT is a concept in neurodegeneration research. Key relationships include: regulates, inhibits, protects against. Associated with Alzheimer's disease, cerebral ischemia-reperfusion injury. Connected to 28 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	PI3K/AKT
Key Genes/Proteins	NRF2, GLUT1, HK2, PKM2
Related Diseases	ischemic stroke, Cancer, depression
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PI3K_AKT["PI3K/AKT"]
    PI3K_AKT -->|"activates"| neuronal_survival["neuronal survival"]
    PI3K_AKT -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    PI3K_AKT -->|"activates"| oxidative_stress_resistance["oxidative stress resistance"]
    PI3K_AKT -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    PI3K_AKT -->|"regulates"| mTOR["mTOR"]
    PI3K_AKT -.protects against.-> oxidative_stress["oxidative stress"]
    PI3K_AKT -->|"regulates"| cell_proliferation["cell proliferation"]
    PI3K_AKT -->|"regulates"| apoptosis["apoptosis"]
    PI3K_AKT -->|"regulates"| autophagy["autophagy"]
    NF2["NF2"] -->|"regulates"| PI3K_AKT
    Ginsenoside_Rg1["Ginsenoside Rg1"] -->|"activates"| PI3K_AKT
    acupuncture["acupuncture"] -->|"regulates"| PI3K_AKT
    CCL21["CCL21"] -->|"activates"| PI3K_AKT
    AMPK["AMPK"] -->|"interacts"| PI3K_AKT
    merlin["merlin"] -->|"regulates"| PI3K_AKT
    Rb1["Rb1"] -->|"regulates"| PI3K_AKT
    Ginsenoside_Rb1["Ginsenoside Rb1"] -->|"activates"| PI3K_AKT
    THBS2["THBS2"] -->|"regulates"| PI3K_AKT

Outgoing (271)

Target	Relation	Type	Str
ischemic stroke	regulates	disease	0.95
NRF2	activates	protein	0.95
Cancer	activates	disease	0.95
Aerobic Glycolysis	promotes	process	0.95
osteoblast pyroptosis	inhibits	process	0.92
Renal Tubular Epithelial Cell Apoptosis	mediates	process	0.92
depression	therapeutic_target	disease	0.90
cell proliferation	promotes	process	0.90
cell migration	promotes	process	0.90
cell invasion	promotes	process	0.90
GLUT1	phosphorylates	protein	0.90
HK2	phosphorylates	protein	0.90
PKM2	phosphorylates	protein	0.90
glucose metabolism	regulates	process	0.90
SLC2A1	phosphorylates	gene	0.90
PFKFB3	phosphorylates	gene	0.90
Lipid Metabolism	regulates	process	0.90
Inflammation	regulates	process	0.90
MTOR	activates	gene	0.90
Programmed Cell Death	regulates	process	0.90
Polystyrene Microplastics	inhibits	compound	0.90
Hemorrhagic Stroke	implicated_in	disease	0.90
emotion-related brain regions	expressed_in	brain_region	0.88
Dermatomyositis	upregulates	disease	0.88
APOPTOSIS	regulates	process	0.88
PENTOSE PHOSPHATE PATHWAY	regulates	entity	0.85
LIPID SYNTHESIS	regulates	entity	0.85
OXIDATIVE STRESS	regulates	entity	0.85
Adult Dermatomyositis	upregulates	disease	0.85
neurogenesis	regulates	process	0.85
oxidative stress	modulates	process	0.85
Neural Regeneration	activates	process	0.85
vascularization	promotes	process	0.85
rheumatoid arthritis	associated_with	disease	0.85
Cytokines	regulates	compound	0.85
MTORC1	regulates	protein	0.85
GSK3	regulates	protein	0.85
FOXO	regulates	protein	0.85
VASCULAR BARRIER FUNCTION	promotes	biological_process	0.85
MTOR	regulates	gene	0.85
MYC	regulates	gene	0.85
HIF1A	regulates	gene	0.85
mTOR	activates	protein	0.85
PANoptosis	regulates	process	0.85
Apoptosis	inhibits	process	0.85
Epithelial-Mesenchymal Transition	regulates	process	0.85
Blood-Brain Barrier Integrity	regulates	process	0.85
neuroinflammation	modulates	process	0.80
oxidative stress	prevents	process	0.80
immune regulation	modulates	process	0.80

Incoming (1735)

Source	Relation	Type	Str
Hesperetin	activates	compound	0.95
Quercetin	inhibits	compound	0.93
Luteolin	activates	drug	0.90
NF-κB signaling	interacts_with	pathway	0.85
FDX1	inhibits	gene	0.85
Platelet-Rich Plasma	activates	compound	0.85
Osteoking	activates	drug	0.85
LY294002	inhibits	drug	0.85
Ulva Sp.	inhibits	drug	0.85
Mir-532-5P	activates	biomarker	0.85
Ncrnas	modulates	biomarker	0.85
Crocetin	modulates	compound	0.85
KL	modulates	gene	0.85
NF2	regulates	gene	0.80
Wnt	interacts_with	pathway	0.80
GH	activates	protein	0.80
TRPM	activates	protein	0.80
NUP85	regulates	gene	0.80
MAPK	interacts_with	pathway	0.80
PROANTHOCYANIDINS	regulates	compound	0.80
ANTIOXIDANTS	modulates	compound	0.80
NF-κB	interacts_with	pathway	0.75
FABP4	activates	protein	0.75
acupuncture	regulates	drug	0.70
CCL21	activates	protein	0.70
merlin	regulates	protein	0.70
THBS2	regulates	gene	0.70
CLCN8	associated_with	gene	0.60
APOE	inhibits	gene	0.55
P2RY12	inhibits	gene	0.55
EPHB4	expression	gene	0.55
NTN1	activates	gene	0.55
CGAS	activates	gene	0.55
STING1	activates	gene	0.55
HK2	transports	gene	0.55
GJA1	activates	gene	0.55
LAMP1	activates	gene	0.55
OCLN	activates	gene	0.55
TUBB3	activates	gene	0.55
FOXO1	involved_in	gene	0.55
STX17	activates	gene	0.55
ULK1	activates	gene	0.55
RAB7A	activates	gene	0.55
ANGPT1	involved_in	gene	0.55
ANGPT1	inhibits	gene	0.55
ANGPT1	neuroprotective	gene	0.55
BCL2L1	activates	gene	0.55
IL1B	activates	gene	0.55
DNMT1	activates	gene	0.55
SETX	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PI3K/AKT

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

PD Combination Therapy Matrix

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

NTF4 Protein

TREM2 Mechanism Hub

GSK-3β in Neurodegeneration

Growth Factor Therapies

Tau Spreading Mechanism

ncam2

Neurotrophin Signaling Pathways in Neurodegeneration

amyloid-beta-metalloproteinases

TREM2 Microglial Signaling Pathway in Neurodegeneration

CNTN6 — Contactin 6

Vitamin D Signaling Pathway in Neurodegeneration