gene 891 words KG: PIK3CA 2026-03-24
kind:genesection:genesstate:published
Contents

PIK3CA Gene

🧬 Gene Info
Gene SymbolPIK3CA
Chromosome3q26.32
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight120 kDa
Amino Acids068 aa
Exons21
PathwaysPI3K, mTOR
GeneCardsPIK3CA
Human Protein AtlasPIK3CA
PIP2PIP3
PI(4)PPI(3,4)P2
PIPI(3)P
ApproachAgent
PI3K inhibitorsWortmannin, LY294002
Akt inhibitorsAkti-1/2
Associated DiseasesALS, Aging, BREAST CANCER
Known Drugs/CompoundsChrysotoxine, Apitolisib, Paxalisib, Alpelisib, rapamycin
InteractionsPTEN, AKT, PI3K, MMP9, PPARA, IGF1R
KG Connections779 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
PARP1 Inhibition Therapy
Score: 0.58
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (4)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
AKT3 Gene
gene · KG edge: activates
AKT1 Gene
gene · KG edge: activates
ACVR1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

PIK3CA associated_with GAIN
PIK3CA associated_with GSK3B
PIK3CA regulates AKT
PIK3CA associated_with PARP1
PIK3CA regulates MTOR
PIK3CA inhibits PTEN
PIK3CA associated_with TP53
PIK3CA regulates GAIN
PIK3CA regulates SIRT1
PIK3CA regulates SRC