gene 4,497 words KG: CNTN4 2026-03-25
kind:genesection:genesstate:expanded
Contents

CNTN4 — Contactin 4

🧬 Gene Info
Gene SymbolCNTN4
Full NameContactin 4
Chromosome3
Protein FamilyImmunoglobulin superfamily; Contactin family
Protein TypeGPI-anchored neural cell adhesion molecule
Functionis a GPI-anchored protein that localizes to lipid rafts in neuronal membranes where it mediates cell surface interactions essential for neural circuit formation and maintenance [@pmid_15342350].
Primary ExpressionBrain (cortex, hippocampus, cerebellum), peripheral tissues
Molecular Weight~116 kDa
Amino Acids028 aa
Exons24
UniProt IDQ9C0A2
NCBI Gene ID55299
Ensembl IDENSG00000144619
GeneCardsCNTN4
Human Protein AtlasCNTN4
Associated DiseasesALS, Amyotrophic Lateral Sclerosis
KG Connections77 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (1)

Netrin-1 Gradient Restoration
Score: 0.33

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (6)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (9)

CCNF Protein (Cyclin F)
protein · KG edge: encodes
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: encodes
Packard Center for ALS Research
institution · KG edge: encodes
CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A
gene · KG edge: expressed_in
BID — BH3 Interacting Domain Death Agonist
gene · KG edge: encodes

Knowledge Graph (12 edges)

CNTN4 expressed_in PLIN4
CNTN4 expressed_in BID
CNTN4 expressed_in HNRNPA2B1
CNTN4 expressed_in TDP-43
CNTN4 expressed_in TBC1D24
CNTN4 expressed_in MAPT
CNTN4 expressed_in CDKN1A
CNTN4 expressed_in TIA1
CNTN4 expressed_in FUS
CNTN4 encodes SMN