Contents

CCNF Protein (Cyclin F)

🔬 Protein Info

Gene Symbol	CCNF
Aliases	Cyclin F
Function	Ccnf Protein (Cyclin F) plays an important role in the study of neurodegenerative diseases
Primary Expression	most tissues, with highest expression in:
Subcellular Localization	</th><td>Nucleus, Cytoplasm</td></tr>
Molecular Weight	89.5 kDa
Amino Acids	786 aa
Pathways	Apoptosis, Cell Cycle, apoptosis
GeneCards	CCNF
Human Protein Atlas	CCNF
N-terminal Domain	Contains regulatory elements including phosphorylation sites that modulate protein-protein interactions and substrate binding affinity.
C-terminal Regions	House additional protein interaction motifs and post-translational modification sites.
Phosphorylation	Multiple serine/threonine phosphorylation sites regulate substrate binding and SCF complex assembly. Casein kinase 2 (CK2) phosphorylation enhances CCNF activity[@shimizu2018].
Ubiquitination	As an E3 ligase, CCNF itself can be ubiquitinated, leading to proteasomal degradation in a feedback regulatory mechanism.
Sumoylation	SUMO modification influences nuclear-cytoplasmic trafficking and protein stability.
Associated Diseases	frontotemporal dementia
Interactions	ALS, AND, APOPTOSIS, CDKN1A, CHCHD10, MATR3
KG Connections	113 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph