gene 1,879 words KG: PLIN4 2026-03-27
kind:genesection:genesstate:publishedlipid-dropletperilipinlipid-metabolismadipocyteneurodegeneration
Contents

PLIN4 Gene

🧬 Gene Info
Gene SymbolPLIN4
Functionencodes a member of the perilipin family of proteins that are essential regulators of lipid droplet formation, storage, and mobilization.
Primary Expressionneurons and glial cells, where they participate in lipid droplet dynamics relevant to neurodegenerative processes in Alzheimer's disease (AD), Parkins
Molecular Weight50 kDa
Amino Acids456 aa
Ensembl IDENSG00000146383
GeneCardsPLIN4
Human Protein AtlasPLIN4
Associated Diseasesneurodegeneration
InteractionsBCL2, CARD14, TBC1D24, MITOPHAGY
KG Connections86 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.48
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

CCNF Protein (Cyclin F)
protein · KG edge: expressed_in
Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: encodes
Packard Center for ALS Research
institution · KG edge: encodes
Alzheimer Indonesia
institution · KG edge: protects_against

Knowledge Graph (12 edges)

PLIN4 protects_against BDNF
PLIN4 inhibits BCL2
PLIN4 inhibits CARD14
PLIN4 protects_against APP
PLIN4 expressed_in BID
PLIN4 expressed_in HNRNPA2B1
PLIN4 expressed_in TDP-43
PLIN4 expressed_in TBC1D24
PLIN4 expressed_in MAPT
PLIN4 expressed_in CDKN1A