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gene 695 words KG: HNRNPA1
Contents

HNRNPA1 Gene

🧬 Gene Info
Gene SymbolHNRNPA1
AliasesPage for HNRNPA1
Chromosome12q13.13
FunctionIn neurons and other cell types, hnRNP A1 plays critical roles in multiple aspects of RNA metabolism and cellular stress response:
Primary ExpressionUbiquitous, high in brain and muscle
Molecular Weight38 kDa
Amino Acids372 aa
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDP09651
NCBI Gene ID3178
Ensembl IDENSG00000166086
OMIM164017
GeneCardsHNRNPA1
Human Protein AtlasHNRNPA1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Anxiety, Cancer, Carcinoma, dementia
Known Drugs/CompoundsPACLITAXEL
InteractionsAGING, ALOX15, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, APP
KG Connections416 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69CYP46A1 Overexpression Gene Therapy
Score: 0.77PARP1 Inhibition Therapy
Score: 0.74Phase-Separated Organelle Targeting
Score: 0.73Stress Granule Phase Separation Modulators
Score: 0.72Autophagosome Maturation Checkpoint Control
Score: 0.71Axonal RNA Transport Reconstitution
Score: 0.70Cross-Seeding Prevention Strategy
Score: 0.69RNA Granule Nucleation Site Modulation
Score: 0.66Arginine Methylation Enhancement Therapy
Score: 0.65Nucleolar Stress Response Normalization
Score: 0.65Glycine-Rich Domain Competitive Inhibition
Score: 0.64Low Complexity Domain Cross-Linking Inhibition
Score: 0.62SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61VCP-Mediated Autophagy Enhancement
Score: 0.59Cryptic Exon Silencing Restoration
Score: 0.53RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (8)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (10)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_withAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: stabilizesALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activatesATM Gene
gene · KG edge: regulatesATR Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

HNRNPA1 associated_with VALOSIN
USP7 inhibits HNRNPA1
HNRNPA1 inhibits ALOX15
JUN activates HNRNPA1
RANK activates HNRNPA1
RANKL activates HNRNPA1
GAIN activates HNRNPA1
PTBP1 expressed_in HNRNPA1
TARDBP expressed_in HNRNPA1
CALCOCO2 activates HNRNPA1

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