gene 695 words KG: HNRNPA1 2026-03-21
kind:genesection:genesstate:published
Contents

HNRNPA1 Gene

🧬 Gene Info
Gene SymbolHNRNPA1
Full NameHeterogeneous Nuclear Ribonucleoprotein A1
AliasesPage for HNRNPA1
Chromosome12q13.13
FunctionIn neurons and other cell types, hnRNP A1 plays critical roles in multiple aspects of RNA metabolism and cellular stress response:
Primary ExpressionUbiquitous, high in brain and muscle
Molecular Weight38 kDa
Amino Acids372 aa
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDP09651
NCBI Gene ID3178
Ensembl IDENSG00000166086
OMIM164017
GeneCardsHNRNPA1
Human Protein AtlasHNRNPA1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Anxiety, Cancer, Carcinoma, Dementia
Known Drugs/CompoundsPACLITAXEL
InteractionsALOX15, USP7, RANK, RANKL, CALCOCO2, NDP52
KG Connections452 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (17)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Phase-Separated Organelle Targeting
Score: 0.52
Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: encodes
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: expressed_in
ATXN2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

HNRNPA1 inhibits ALOX15
HNRNPA1 associated_with VALOSIN
HNRNPA1 inhibits USP7
HNRNPA1 associated_with VCP
HNRNPA1 associated_with TIA1
HNRNPA1 contributes_to VCP
HNRNPA1 activates RANK
HNRNPA1 activates RANKL
HNRNPA1 contributes_to TIA1
HNRNPA1 activates CALCOCO2