gene 1,383 words KG: CRKL 2026-03-24
kind:genesection:genesstate:published
Contents

CRKL Gene

🧬 Gene Info
Gene SymbolCRKL
AliasesCRK-like proto-oncogene
Chromosome22q11.21
Protein TypeAdaptor Protein
Functionis a gene encoding an adaptor protein that plays critical roles in intracellular signal transduction.
Subcellular LocalizationCytoplasm, plasma membrane
Molecular Weight~34 kDa
Amino Acids303 aa
Exons12
PathwaysMAPK pathway
UniProt IDP46109
NCBI Gene ID1399
GeneCardsCRKL
Human Protein AtlasCRKL
Gene NameCRK-like proto-oncogene adaptor protein
Associated Diseasesneurodegeneration
KG Connections12 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Packard Center for ALS Research
institution · KG edge: regulates
YWHAH Gene — 14-3-3 Eta (η) Protein
gene · KG edge: associated_with
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
NDUFS6 Gene
gene · KG edge: associated_with
NDUFS5 — NADH:Ubiquinone Oxidoreductase Core Subunit S5
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CRKL associated_with DOCK1
CRKL associated_with NDUFA12
CRKL associated_with YWHAH
CRKL associated_with NDUFS5
CRKL regulates Als
CRKL regulates Ms
NDUFA2 associated_with CRKL
NDUFS6 associated_with CRKL
NDUFA1 associated_with CRKL
CBL associated_with CRKL