gene 2,503 words KG: DOCK1 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:cytoskeletontopic:signal-transduction
Contents

DOCK1 Gene

🧬 Gene Info
Gene SymbolDOCK1
Full NameDedicator of Cytokinesis 1
Chromosome10q26.3
Functionis a member of the DOCK family of guanine nucleotide exchange factors (GEFs) that specifically activate Rho GTPases, particularly Rac1.
Primary ExpressionBrain, Heart, Liver, Lung, Kidney
Molecular Weight210 kDa
Amino Acids1864 aa
Exons35
UniProt IDQ8IU85
NCBI Gene ID1791
Ensembl IDENSG00000123146
OMIM606003
GeneCardsDOCK1
Human Protein AtlasDOCK1
Protein ClassRho GTPase guanine nucleotide exchange factor (GEF)
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections12 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.42

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Packard Center for ALS Research
institution · KG edge: regulates
YWHAH Gene — 14-3-3 Eta (η) Protein
gene · KG edge: associated_with
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
NDUFS6 Gene
gene · KG edge: associated_with
NDUFS5 — NADH:Ubiquinone Oxidoreductase Core Subunit S5
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DOCK1 associated_with NDUFA12
DOCK1 associated_with YWHAH
DOCK1 associated_with NDUFS5
DOCK1 regulates Als
DOCK1 regulates Ms
NDUFA2 associated_with DOCK1
NDUFS6 associated_with DOCK1
NDUFA1 associated_with DOCK1
CBL associated_with DOCK1
PDGFRB associated_with DOCK1