gene 1,841 words KG: HSP90AB1
Contents

HSP90AB1 Gene

🧬 Gene Info
Gene SymbolHSP90AB1
Chromosome6p21.1
Molecular Weight90 kDa
Amino Acids724 aa
Exons11
PathwaysLipid Metabolism, Autophagy, Blood-Brain Barrier, Mapk, Apoptosis
GeneCardsHSP90AB1
Human Protein AtlasHSP90AB1
CategoryClient Proteins
KinasesAKT, RAF, SRC
Steroid receptorsER, PR, AR
Transcription factorsp53, HIF-1α
Cell cycleCDK4, CDK6
ChaperonesHSP70, HSP40
DiseaseHSP90AB1 Role
Associated DiseasesAging, Als, Cancer, Ms
InteractionsACTB, CDC42, ATP5A1, SOD1, EGFR, SNCA
KG Connections191 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in
DNAJC10 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

HSP90AB1 associated_with MAP1LC3B
HSP90AB1 expressed_in MDM2
HSP90AB1 expressed_in HSF1
HSP90AB1 expressed_in GRB2
HSP90AB1 expressed_in UBC
HSP90AB1 expressed_in CELF2
HSP90AB1 expressed_in JUN
HSP90AB1 interacts_with ACTB
HSP90AB1 interacts_with CDC42
HSP90AB1 interacts_with ATP5A1