gene 1,598 words KG: NDUFS5 2026-03-28
kind:genesection:genesstate:publishedevidence:strong
Contents

NDUFS5 — NADH:Ubiquinone Oxidoreductase Core Subunit S5

🧬 Gene Info
Gene SymbolNDUFS5
Full NameNADH:Ubiquinone Oxidoreductase Core Subunit S5
Chromosome1p33
Protein FamilyComplex I accessory subunits
Functionencodes an accessory subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), the largest enzyme of the mitochondrial electron transport chain [[brandt1999]](https://pubmed.
Molecular Weight15 kDa
UniProt IDO43920
NCBI Gene ID4723
Ensembl IDENSG00000168653
OMIM603835
GeneCardsNDUFS5
Human Protein AtlasNDUFS5
Alias15 kDa subunit, CI15
Associated DiseasesParkinson's Disease, Leigh Syndrome, Mitochondrial Complex I Deficiency, Alzheimer's Disease
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (12)

Packard Center for ALS Research
institution · KG edge: regulates
YWHAH Gene — 14-3-3 Eta (η) Protein
gene · KG edge: associated_with
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
NDUFS6 Gene
gene · KG edge: associated_with
NDUFA2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NDUFS5 provides_data_for ds-83b31ef18d49
NDUFS5 regulates Als
NDUFS5 regulates Ms
NDUFS5 data_in benchmark_ot_ad_answer_key:NDUFS5
ds-83b31ef18d49 data_in NDUFS5
NDUFA2 associated_with NDUFS5
NDUFS6 associated_with NDUFS5
NDUFA1 associated_with NDUFS5
CBL associated_with NDUFS5
PDGFRB associated_with NDUFS5