gene 2,068 words KG: YWHAH 2026-03-27
kind:genesection:genesstate:published
Contents

YWHAH Gene — 14-3-3 Eta (η) Protein

🧬 Gene Info
Gene SymbolYWHAH
Full NameTyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta
Aliases14-3-3 Eta (η) Protein
Chromosome22q12.3
FunctionPhosphorylation: Affects target protein binding affinity
Primary Expressionall eukaryotic cells[@yau2015]
Molecular Weight28 kDa
Amino Acids246 aa
Exons6
UniProt IDQ9Y2H5
NCBI Gene ID7535
Ensembl IDENSG00000128245
OMIM608456
GeneCardsYWHAH
Human Protein AtlasYWHAH
Associated Diseasesneurodegeneration
InteractionsFUS, IL-6, YES1, SOX9, HNRNPA2B1, AND
KG Connections25 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Axonal RNA Transport Reconstitution
Score: 0.45
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: regulates
YES1 — YES Proto-Oncogene 1, Src Family Tyrosine Kinase
gene · KG edge: activates
SOX9 Gene
gene · KG edge: activates
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
NDUFS6 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

YWHAH associated_with NDUFS5
YWHAH activates FUS
YWHAH regulates Als
YWHAH regulates Ms
YWHAH activates IL-6
YWHAH activates Carcinoma
YWHAH activates Cancer
YWHAH activates Tumor
NDUFA2 associated_with YWHAH
NDUFS6 associated_with YWHAH