gene 1,801 words KG: CSPG4 2026-03-27
kind:genesection:genesstate:published
Contents

CSPG4

🧬 Gene Info
Gene SymbolCSPG4
Full NameChondroitin Sulfate Proteoglycan 4
AliasesCSPG4 (NG2)
Chromosome15q24.2
Protein TypeReceptor
Functionencodes a large cell surface proteoglycan that is primarily expressed on pericytes and mesenchymal progenitor cells [1](https://pubmed.
Molecular Weight400 kDa
Amino Acids224 aa
Exons33
UniProt ID[Q6UVK1](https://www.uniprot.org/uniprot/Q6UVK1)
Ensembl IDENSG00000173546
GeneCardsCSPG4
Human Protein AtlasCSPG4
N-terminal Signal PeptideDirects cotranslational translocation to the ER
Associated DiseasesALS
InteractionsHSPG2, PROGRANULIN, NOTCH, Proteins, INFLAMMATION, BRAIN INJURY
KG Connections20 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Glycosaminoglycan Template Disruption Approach
Score: 0.46
Glial Glycocalyx Remodeling Therapy
Score: 0.41
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44
Retinal Vascular Microcirculation Rescue
Score: 0.54
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.50

Related Analyses (2)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
Biomechanical Impact Profiles and Chronic Traumatic Encephal
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Traumatic Brain Injury and Alzheimer's Disease Relationship
validation · proposed · Score: 0.40
Biomechanical Impact Profiles and Chronic Traumatic Encephal
clinical · proposed · Score: 0.40

See Also (10)

Proteins
index · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: interacts_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: expressed_in
Astrocytes
entity · KG edge: regulates
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

CSPG4 interacts_with HSPG2
CSPG4 associated_with PROGRANULIN
CSPG4 interacts_with PROGRANULIN
CSPG4 binds_to HSPG2
CSPG4 regulates AXON
CSPG4 regulates AND
CSPG4 regulates ASTROCYTES
CSPG4 interacts_with NOTCH
CSPG4 interacts_with ALS
CSPG4 interacts_with Inflammation