gene 1,700 words KG: DLL1 2026-03-29
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

DLL1 Gene

🧬 Gene Info
Gene SymbolDLL1
Full NameDelta-Like 1
Chromosome6q27
Functionencodes a transmembrane ligand of the Delta/Serrate/Lag-2 (DSL) family that activates Notch receptors through cell-cell contact.
Primary ExpressionBrain (hippocampus, cortex, SVZ), neural stem cells, neurons, astrocytes
Molecular Weight~82 kDa
Amino Acids723 aa
Exons24
PathwaysNotch, Notch signaling
UniProt IDO00548
NCBI Gene ID28514
Ensembl IDENSG00000198719
OMIM604552
GeneCardsDLL1
Human Protein AtlasDLL1
Associated DiseasesAls, Autism
KG Connections25 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (9)

Sphingolipid Metabolism in Neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: associated_with
NOS2 - Nitric Oxide Synthase 2
gene · KG edge: therapeutic_target
ESR1 — Estrogen Receptor Alpha
gene · KG edge: therapeutic_target
Class II Major Histocompatibility Complex Transactivato
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

DLL1 regulates BACE1
DLL1 regulates NDRG2
DLL1 regulates NLRP3
DLL1 associated_with NOTCH1
DLL1 participates_in Notch signaling
DLL1 associated_with Als
DLL1 associated_with Autism
DLL1 associated_with Notch
DLL1 regulates Als
DLL1 regulates Ms