gene

ABCB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

652Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

ABCB1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with AD, ALS, Aging. Connected to 366 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCB1
Full Name	ATP Binding Cassette Subfamily B Member 1
Chromosome	7q21.12
Protein Type	Transporter
Target Class	Transporter
Function	encodes a 170 kDa ATP-dependent efflux transporter that is a critical component of the blood-brain barrier.
Mechanism of Action	Small molecule inhibitors to reduce efflux pump activity and enhance CNS drug penetration
Primary Expression	the cortex and hippocampus, with moderate levels in the cerebellum and brainstem
Druggability	Medium (0.47)
Clinical Stage	Phase III
Molecular Weight	170 kDa
Exons	29
Pathways	Apoptosis, Blood-Brain Barrier, Ferroptosis, Nf-Κb, Notch
Ensembl ID	ENSG00000085563
GeneCards	ABCB1
Human Protein Atlas	ABCB1
Associated Diseases	AD, ALS, Aging, Alzheimer, Alzheimer'S Disease
Known Drugs/Compounds	Tariquidar, Elacridar
Interactions	TFR1, LRP1, CAV1, TNF, ABCG2, KMT2A
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	651 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: ABCB1 — PDB 6QEX Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCB1["ABCB1"] -->|"activates"| Cancer["Cancer"]
    ABCB1["ABCB1"] -->|"activates"| Carcinoma["Carcinoma"]
    ABCB1["ABCB1"] -->|"activates"| Ms["Ms"]
    ABCB1["ABCB1"] -->|"associated"| Alzheimer["Alzheimer"]
    ABCB1["ABCB1"] -->|"therapeutic target"| Dementia["Dementia"]
    ABCB1["ABCB1"] -->|"associated"| Depression["Depression"]
    h_84808267["h-84808267"] -->|"therapeutic target"| ABCB1["ABCB1"]
    TFR1["TFR1"] -->|"interacts"| ABCB1["ABCB1"]
    LRP1["LRP1"] -->|"interacts"| ABCB1["ABCB1"]
    CAV1["CAV1"] -->|"interacts"| ABCB1["ABCB1"]
    style ABCB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (478)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.85
Als	therapeutic_target	disease	0.85
Alzheimer's Disease	involved_in	disease	0.85
Alzheimer'S Disease	involved_in	disease	0.85
antidepressant drugs	regulates	drug	0.80
metabolic homeostasis	involved_in	process	0.80
Blood-Brain Barrier	involved_in	process	0.80
P_glycoprotein	encodes	protein	0.80
CANCER	therapeutic_target	gene	0.80
Cancer	activates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
MYC	therapeutic_target	gene	0.70
APOE	modulates	gene	0.70
hepatotoxicity	protects_against	phenotype	0.70
Epigenetic	therapeutic_target	pathway	0.70
Notch	therapeutic_target	pathway	0.70
CANCER	activates	gene	0.70
Chemoresistance	therapeutic_target	pathway	0.70
neural stem cells	regulates	cell_type	0.70
blood-brain barrier	participates_in	pathway	0.70
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Dementia	associated_with	disease	0.65
Als	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Als	interacts_with	disease	0.65

Incoming (174)

Source	Relation	Type	Str
h-84808267	targets_gene	hypothesis	0.90
DOT1L	regulates	gene	0.80
CD44	therapeutic_target	gene	0.70
TFR1	interacts_with	gene	0.65
LRP1	interacts_with	gene	0.65
CAV1	interacts_with	gene	0.65
DOT1L	contributes_to	gene	0.60
PLCG2	contributes_to	gene	0.60
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
JUN	activates	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
UBIQUITIN	biomarker_for	gene	0.60
NR3C1	interacts_with	gene	0.60
NEIL1	activates	gene	0.60
NEIL3	activates	gene	0.60
BRAF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ABCB1

Understanding Entity Pages

Summary

Wiki Pages (21)

ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member 1

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Blood-Brain Barrier Dysfunction in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

Exosome and Extracellular Vesicle Brain Delivery

bbb-transport-mechanisms

Blood-Brain Barrier Breakdown in Neurodegeneration

blood-brain-barrier-endothelial-cells

Exosome-Based Drug Delivery for CBS/PSP

Riluzole ALS Trials

Blood-Based Biomarkers for Neurodegeneration

potassium-channel-openers-parkinsons

Blood Microbial Signatures in Parkinson's Disease

brain-computer-interface

Amyloid-Beta (Aβ)

CAV1

Blood-Brain Barrier

slc22a1