gene 1,660 words KG: DNAJB12 2026-03-27
kind:genesection:genesstate:published
Contents

DNAJB12 — DnaJ Heat Shock Protein Family (Hsp40) Member B12

🧬 Gene Info
Gene SymbolDNAJB12
Full NameDnaJ Heat Shock Protein Family (Hsp40) Member B12
Chromosome10q24.3
Protein TypeChaperone
Functionis a crucial co-chaperone protein that plays essential roles in protein quality control, ER-associated degradation (ERAD), and cellular proteostasis.
Subcellular LocalizationDNAJB12 exhibits dual localization:
Molecular Weight~36 kDa
Amino Acids324 aa
UniProt IDQ9Y5W2
NCBI Gene ID54795
Ensembl IDENSG00000135924
OMIM614152
GeneCardsDNAJB12
Human Protein AtlasDNAJB12
Transcript Length~1.8 kb coding sequence
Associated DiseasesAmyotrophic Lateral Sclerosis, Parkinson's Disease, Huntington's Disease
KG Connections6 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.42
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (2)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (4)

STK4 — Serine/Threonine Kinase 4
gene · KG edge: regulates
SCN4B Gene - Sodium Voltage-Gated Channel Beta Subunit
gene · KG edge: regulates
RB1CC1 Gene
gene · KG edge: regulates
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (6 edges)

DNAJB12 regulates RB1CC1
DNAJB12 regulates SCN4B
DNAJB12 regulates STK4
DNAJB12 activates Anxiety
DNAJB12 regulates Ms
DNAJB12 activates Depression