gene 1,251 words KG: ELAVL3 2026-03-24
kind:genesection:genesstate:published
Contents

ELAVL3 Gene

🧬 Gene Info
Gene SymbolELAVL3
FunctionELAVL3 is a 367 amino acid protein characterized by its neuron-specific expression pattern and its critical functions in post-transcriptional gene regulation
Primary ExpressionSpinal Cord
Molecular Weight39 kDa
Amino Acids367 aa
PathwaysOxidative Stress, Apoptosis, Autophagy
GeneCardsELAVL3
Human Protein AtlasELAVL3
mRNA StabilizationBinding to 3' UTR AREs
Translational ActivationRecruiting translation machinery
Translational RepressionBlocking translation initiation
Alternative SplicingNuclear splicing regulation
ConditionELAVL3 Association
Frontotemporal DementiaAltered expression in FTD-TDP
Huntington's DiseaseTranscriptional dysregulation
Associated Diseasesneurodegeneration
InteractionsMANF, MBP, GFAP, GAP43, MAP1LC3B, TUBULIN
KG Connections64 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
MANF Gene
gene · KG edge: inhibits
GAP43 Gene
gene · KG edge: inhibits
Genes
index · KG edge: inhibits

Knowledge Graph (12 edges)

ELAVL3 regulates GAP43
ELAVL3 regulates GFAP
ELAVL3 regulates MANF
ELAVL3 regulates MBP
ELAVL3 regulates TUBULIN
ELAVL3 inhibits MANF
ELAVL3 inhibits MBP
ELAVL3 inhibits GFAP
ELAVL3 inhibits GAP43
ELAVL3 upregulates TREM2