gene 3,199 words KG: EPHA8 2026-03-25
kind:genesection:genesstate:published
Contents

EPHA8 Gene

🧬 Gene Info
Gene SymbolEPHA8
Full NameEphrin Type-A Receptor 8
Chromosome1p36.22
Protein TypeReceptor
FunctionHippocampal Function: EPHA8 is highly expressed in CA1 pyramidal neurons where it regulates synaptic plasticity and spatial memory formation[@li2019].
Primary ExpressionPyramidal neurons, Interneurons, Glia
Molecular Weight105 kDa
Amino Acids986 aa
Exons18
UniProt IDQ9Y232
NCBI Gene ID2045
Ensembl IDENSG00000077312
OMIM603306
GeneCardsEPHA8
Human Protein AtlasEPHA8
Associated DiseasesAlzheimer's Disease, Parkinson's Disease
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

p38 MAPK Protein
protein · KG edge: associated_with
Proteins
index · KG edge: associated_with
Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: regulates
Interferon Signaling in Neurodegeneration
mechanism · KG edge: regulates
GSK3 Signaling in Parkinson's Disease
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

EPHA8 associated_with P38
EPHA8 associated_with PI3K
EPHA8 associated_with ERK1
EPHA8 regulates LRRN1
EPHA8 regulates SMPD1
EPHA8 associated_with GSK3
EPHA8 regulates Als
EPHA8 regulates Cancer
EPHA8 regulates Neuron
EPHA8 associated_with AND