gene 585 words KG: GAIN 2026-03-24
kind:genesection:genesstate:published
Contents

GAIN Gene - GABA-A Receptor Associated Protein Like 2

🧬 Gene Info
Gene SymbolGAIN
Full NameGAIN - GABA-A Receptor Associated Protein Like 2
AliasesPage for GAIN Gene, GABARAPL2
Chromosome16p13.3
Protein TypeGene
Functionencodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family.
Primary Expressionvarious tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism
NCBI Gene ID124454
GeneCardsGAIN
Human Protein AtlasGAIN
Associated DiseasesALS, Aging, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
InteractionsTKT, GABRA1, ALOX15, HNRNPA2B1, HNRNPA1, OVERVIEW
KG Connections1953 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (30)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates
ALDH1A1 Gene
gene · KG edge: therapeutic_target
AIF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

GAIN activates TKT
GAIN biomarker_for TREM2
GAIN inhibits GABRA1
GAIN associated_with DLK1
GAIN activates ALOX15
GAIN activates HNRNPA2B1
GAIN activates HNRNPA1
GAIN interacts_with OVERVIEW
GAIN inhibits PP2A
GAIN inhibits STAR