| Gene Symbol | P38 |
| Chromosome | MAPK14: 6p21.31, MAPK11: 22q13.13, MAPK12: 15q21.2, MAPK13: 6p21.31 |
| Protein Type | Kinase |
| Function | Upstream stress signals: Pro-inflammatory cytokines (IL-1β, TNF-α), oxidative stress, UV radiation, heat shock, and ischemia trigger activation |
| Primary Expression | neurons, microglia, and astrocytes |
| Molecular Weight | ~38-40 kDa per isoform |
| Pathways | Akt, Apoptosis, Autophagy, Differentiation, Glycolysis |
| GeneCards | P38 |
| Human Protein Atlas | P38 |
| Gene Symbols | MAPK14 (p38α), MAPK11 (p38β), MAPK12 (p38γ), MAPK13 (p38δ) |
| UniProt IDs | Q16539 (p38α), P53778 (p38β), P53779 (p38γ), O15264 (p38δ) |
| Brain Expression | p38α: ubiquitous in neurons, microglia, astrocytes; p38β: lower expression; p38γ/p38δ: restricted |
| ATF2 | Phosphorylation |
| CHOP (DDIT3) | Phosphorylation |
| MAPKAPK2/3 | Kinase |
| Associated Diseases | Als, Alzheimer, Cancer, Carcinoma, Cardiac, Cardiovascular |
| Known Drugs/Compounds | RAPAMYCIN, N-ACETYLCYSTEINE, Paeoniflorin |
| Interactions | PIK3C3, AKT1, DDIT3, IFNG, PI3K, OPTN |
| KG Connections | 1726 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |