mechanism 2,331 words KG: GSK3 2026-04-01
kind:section:mechanismsevidence:strongmechanismsection:mechanismsstate:publishedgsk3parkinsonstaualpha-synucleinmitochondrial-dysfunctionneuroinflammation
Contents

GSK3 Signaling in Parkinson's Disease

Mechanism Info
NameGSK3
SummaryGSK3-beta role in tau phosphorylation, alpha-synuclein phosphorylation, mitochondrial dysfunction, and neuroinflammation in Parkinson's disease and related disorders
Key Genes/ProteinsAKT, MTOR, MAPK, ERK, CDK5
Related DiseasesALZHEIMER'S DISEASE, neurodegeneration
Related PathwaysWnt signaling, Pi3K/Akt Pathway, PI3K/AKT, MAPK signaling, oxidative stress response

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Vagal Afferent Microbial Signal Modulation
Score: 0.52
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (30)

AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

See Also (3)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

GSK3 interacts_with MTOR
GSK3 therapeutic_target NEUROINFLAMMATION
GSK3 associated_with TAU
GSK3 therapeutic_target PARKINSON'S DISEASE
GSK3 contributes_to HUNTINGTON
GSK3 contributes_to HUNTINGTIN
GSK3 therapeutic_target AMYLOID
GSK3 associated_with ALZHEIMER
GSK3 contributes_to HUNTINGTON'S DISEASE
GSK3 associated_with CDK5