gene 697 words KG: GAK 2026-03-24
kind:genesection:genesstate:published
Contents

GAK Gene

🧬 Gene Info
Gene SymbolGAK
Chromosome6p21.1.
Protein TypeSerine/Threonine Kinase
Functionis a serine/threonine kinase encoded by the GAK gene on chromosome 6p21.
Molecular Weight165 kDa
Amino Acids505 aa
Exons43
PathwaysmTOR
GeneCardsGAK
Human Protein AtlasGAK
LRRK2Physical binding
ClathrinDirect binding
Hsc70Physical binding
ULK1Direct binding
APPIndirect (trafficking)
Associated DiseasesAls, Ms, Parkinson
KG Connections29 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (16)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: expressed_in
SYNJ1 — Synaptojanin 1
gene · KG edge: associated_with
PARKIN Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GAK associated_with SYNJ1
GAK associated_with DNAJC6
GAK associated_with PARK2
GAK associated_with GBA
GAK associated_with SNCA
GAK associated_with AUTOPHAGY
GAK associated_with GENE MUTATIONS
GAK associated_with Parkinson
GAK associated_with Als
GAK associated_with Ms