gene 2,470 words KG: SYNJ1 2025-03-25
kind:genesection:genesstate:published
Contents

SYNJ1 — Synaptojanin 1

🧬 Gene Info
Gene SymbolSYNJ1
Full NameSynaptojanin 1
Chromosome21q22.11
Protein TypePhosphatase
FunctionSYNJ1 is crucial for synaptic vesicle cycling
Primary ExpressionNeuron-enriched
Molecular Weight165 kDa
Amino Acids428 aa
Exons31
PathwaysEndosomal Sorting
UniProt IDSYNJ1
GeneCardsSYNJ1
Human Protein AtlasSYNJ1
FeatureSYNJ1
Amino acids1,428
Associated DiseasesAls, Cancer, Ms, Parkinson
InteractionsVPS35, VPS13C, ATP13A2, DNAJC6, FBXO7, PINK1
KG Connections79 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

APOE-Dependent Autophagy Restoration
Score: 0.61
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.38
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44

Related Analyses (3)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: associated_with
VPS35 — Vacuolar Protein Sorting 35 Homolog
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SYNJ1 associated_with DNAJC6
SYNJ1 associated_with PARK2
SYNJ1 associated_with VPS35
SYNJ1 associated_with PRKN
SYNJ1 interacts_with VPS35
SYNJ1 regulates Endosomal Sorting
SYNJ1 modulates Dopamine Release
SYNJ1 interacts_with VPS13C
SYNJ1 expressed_in VPS13C
SYNJ1 associated_with Parkinson