gene 2,524 words KG: PARK2 2026-03-24
kind:genesection:genesstate:published
Contents

PARK2 - Parkin

🧬 Gene Info
Gene SymbolPARK2
Full NameParkin
Chromosome6q26
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight52 kDa
Amino Acids465 aa
Exons12
PathwaysApoptosis, Immune Response, Mitophagy
Ensembl IDENSG00000185345
GeneCardsPARK2
Human Protein AtlasPARK2
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/CompoundsTHSG, levodopa
InteractionsMAP1LC3B, PINK1, ATG5, LC3, TIMM17A, EIF2A
KG Connections502 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (24)

Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Autophagosome Maturation Checkpoint Control
Score: 0.49
Mitochondrial Transfer Pathway Enhancement
Score: 0.44
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (8)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (6)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: degrades
Alzheimer Indonesia
institution · KG edge: associated_with
ATP13A2 — ATPase Cation Transporting 13A2
gene · KG edge: associated_with
ATM Gene
gene · KG edge: contributes_to

Knowledge Graph (12 edges)

PARK2 activates MAP1LC3B
PARK2 associated_with SQSTM1
PARK2 associated_with BNIP3L
PARK2 associated_with BCL2
PARK2 associated_with MAP1LC3A
PARK2 associated_with MAP1LC3B
PARK2 associated_with COX4I1
PARK2 associated_with PRKN
PARK2 associated_with LC3
PARK2 associated_with NBR1