gene 549 words KG: GAT1 2026-03-16
kind:genesection:genesstate:published
Contents

GABA Transporter 1

🧬 Gene Info
Gene SymbolGAT1
Full NameGABA Transporter 1
Protein TypeGene
Functionis a sodium-dependent GABA transporter that reuptakes GABA from the synaptic cleft back into presynaptic neurons and surrounding glial cells[@borden1994].
Amino Acids599 aa
Pathwaysoxidative stress response
NCBI Gene IDSearch NCBI
GeneCardsGAT1
Human Protein AtlasGAT1
Associated DiseasesAls
InteractionsIRF3, STING, GAT3
KG Connections23 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (3)

Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.43
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.37

Related Analyses (5)

Metabolomic signatures of neurodegeneration and energy metab
neurodegeneration · failed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: associated_with
STING Gene
gene · KG edge: activates
SLC6A13 Gene
gene · KG edge: associated_with
IRF3 Gene
gene · KG edge: activates
GABA Transporter 3 (GAT3)
gene · KG edge: activates

Knowledge Graph (12 edges)

GAT1 regulates AQP1
GAT1 regulates CFTR
GAT1 activates IRF3
GAT1 activates STING
GAT1 transports AQP1
GAT1 transports CFTR
GAT1 regulates Als
GAT1 associated_with Als
GAT1 activates Ms
GAT1 transports ALS