gene 1,969 words KG: STING 2026-03-25
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:alsstate:published
Contents

STING Gene

🧬 Gene Info
Gene SymbolSTING (TMEM173)
Full NameStimulator of Interferon Genes
AliasesTMEM173
Chromosome5q31.2
Functionis a transmembrane protein that serves as the central signaling hub for the cGAS-STING pathway, one of the most important innate immune sensing mechanisms in eukaryotic cells.
Molecular Weight42 kDa
Amino Acids379 aa
Exons6
PathwaysNF-κB
UniProt IDQ86WV1
NCBI Gene ID340061
Ensembl IDENSG00000184584
OMIM612374
Encoded ProteinSTING protein (379 aa)
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/CompoundsMELATONIN, curcumin, resveratrol, quercetin, dimethyl fumarate, DEXAMETHASONE
InteractionsPARP1, IRF3, CD68, TBK1, GPX4, CGAS
KG Connections2990 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (30)

What determines the specificity of TDP-43-induced mitochondr
neurodegeneration · failed
How does chronic cGAS/STING activation downstream of TDP-43
neuroinflammation · failed
What upstream mechanisms cause TDP-43 to trigger mPTP openin
neurodegeneration · failed
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (9)

cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95
TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90
TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90
cGAMP biomarker analysis in ALS patient spinal cord samples
clinical · proposed · Score: 0.85
cGAS/STING pathway validation in TDP-43 mutant mice
validation · proposed · Score: 0.85

See Also (7)

Aducanumab (Aduhelm)
therapeutic · KG edge: inhibits
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: accumulates_in
Adaptive Immunity in Neurodegeneration
mechanism · KG edge: causes
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

STING co_discussed TFEB
STING co_discussed TDP-43
STING co_discussed TNF
STING co_discussed VEGF
STING co_discussed TREM2
STING co_discussed ULK1
STING co_discussed TAU
STING mediates TNF
STING upregulates TAU
STING activates INTERFERON ACTIVATION