| Gene Symbol | IRF3 |
| Chromosome | 19q13.33 |
| Protein Type | Transcription Factor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | most cell types, including:
- Neurons and astrocytes in the brain
- Microglia
- Pe |
| Molecular Weight | 47 kDa |
| Amino Acids | 424 aa |
| Exons | 10 |
| Pathways | Akt, Autophagy, Innate Immunity, Nf-Κb, Pi3K |
| NCBI Gene ID | 7099 |
| GeneCards | IRF3 |
| Human Protein Atlas | IRF3 |
| Disease | Mechanism |
| Alzheimer's Disease | Neuroinflammation, microglial activation |
| Parkinson's Disease | α-Synuclein-induced inflammation |
| Associated Diseases | AD, ALI, ALS, Atherosclerosis, Infection |
| Interactions | PARP1, TBK1, EZH2, CCL5, VDAC1, MAX |
| KG Connections | 456 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |